GRE Sentence Completion

In this biography we are given a glimpse of the young man ____ pursuing the path of the poet despite ____ and rejection slips.

A. doggedly - disappointment
B. tirelessly - encouragement
C. sporadically - awards
D. successfully - acclaim
E. unsuccessfully - failure

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Ans : A. doggedly - disappointment

Explanation : despite denotes something contrary / in opposition